Paul-Martin Holterhus Selected Research

Biomarkers (Surrogate Marker)

1/2022	The adrenal steroid profile in adolescent depression: a valuable bio-readout?
8/2017	Weight loss in obese girls with polycystic ovarian syndrome is associated with a decrease in Anti-Muellerian Hormone concentrations.
6/2009	Apolipoprotein D (APOD) is a putative biomarker of androgen receptor function in androgen insensitivity syndrome.

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Paul-Martin Holterhus Research Topics

Disease

14	Androgen-Insensitivity Syndrome (Testicular Feminization) 05/2023 - 01/2003
9	Congenital Adrenal Hyperplasia (Hyperplasia, Congenital Adrenal) 01/2018 - 07/2006
6	Virilism (Virilization) 10/2019 - 02/2002
6	Disorders of Sex Development (Intersexuality) 03/2017 - 02/2002
4	Diabetes Mellitus 04/2024 - 06/2019
4	Obesity 01/2022 - 12/2016
4	Weight Loss (Weight Reduction) 01/2022 - 06/2013
3	Neoplasms (Cancer) 05/2023 - 01/2017
3	Hypogonadism (Hypergonadotropic Hypogonadism) 12/2022 - 01/2015
3	Congenital adrenal hyperplasia due to 21 hydroxylase deficiency 01/2018 - 05/2014
3	46,XY Disorder of Sex Development (Male Pseudohermaphroditism) 01/2017 - 01/2013
3	Pseudohypoaldosteronism 05/2013 - 01/2007
2	Sepsis (Septicemia) 10/2023 - 01/2012
2	Birth Weight (Birth Weights) 08/2023 - 03/2017
2	Adrenal Insufficiency (Adrenal Gland Hypofunction) 01/2023 - 01/2013
2	Hyperandrogenism 01/2022 - 08/2017
2	Congenital adrenal hyperplasia due to 11-Beta-hydroxylase deficiency 05/2020 - 05/2014
2	Growth Disorders 01/2018 - 12/2011
2	Infections 01/2018 - 01/2012
2	Insulin Resistance 12/2016 - 06/2013
2	Dyslipidemias (Dyslipidemia) 05/2016 - 07/2014
2	Hypertension (High Blood Pressure) 07/2014 - 01/2011
2	Type 1 Diabetes Mellitus (Autoimmune Diabetes) 06/2013 - 03/2007
1	Cushing Syndrome 02/2024
1	Precursor Cell Lymphoblastic Leukemia-Lymphoma (Acute Lymphoblastic Leukemia) 10/2023
1	Polydactyly (Polydactylism) 01/2023
1	Primary Ovarian Insufficiency 12/2022
1	Cryptorchidism (Undescended Testes) 01/2022
1	Major Depressive Disorder (Major Depressive Disorders) 01/2022
1	Gynecomastia 01/2020
1	Hyponatremia 10/2019
1	Endocrine System Diseases (Endocrine Diseases) 12/2018
1	Hemorrhage 01/2018
1	Infarction (Infarctions) 01/2018
1	Turner Syndrome (Turner's Syndrome) 01/2018
1	Adrenoleukodystrophy (Adrenoleukodystrophy, X-Linked) 01/2018
1	Adrenocortical Carcinoma 01/2018
1	Polycystic Ovary Syndrome (Syndrome, Stein-Leventhal) 08/2017
1	Amenorrhea 01/2017
1	Ketosis 05/2016
1	Hypoglycemia (Reactive Hypoglycemia) 09/2015
1	Gonadal Dysgenesis (Gonadal Agenesis) 01/2015

Drug/Important Bio-Agent (IBA)

18	AndrogensIBA 02/2024 - 06/2005
11	Androgen Receptors (Androgen Receptor)IBA 05/2023 - 01/2003
9	SteroidsIBA 01/2022 - 02/2002
7	Testosterone (Sustanon)FDA Link 01/2022 - 02/2002
6	Hydrocortisone (Cortisol)FDA LinkGeneric 01/2022 - 01/2012
6	Steroid 11-beta-Hydroxylase (11 beta-Hydroxylase)IBA 05/2020 - 07/2006
6	Hormones (Hormone)IBA 01/2018 - 01/2012
4	GlucocorticoidsIBA 10/2023 - 01/2007
3	AldosteroneIBA 10/2023 - 06/2013
3	Biomarkers (Surrogate Marker)IBA 01/2022 - 06/2009
3	Insulin-Like Growth Factor I (IGF-1)IBA 01/2020 - 12/2011
3	Mixed Function Oxygenases (Monooxygenases)IBA 01/2018 - 01/2011
3	Androstenedione (4 Androstene 3,17 dione)IBA 05/2017 - 01/2012
3	SaltsIBA 05/2013 - 04/2008
2	MineralocorticoidsIBA 10/2023 - 06/2013
2	Estradiol (Delestrogen)FDA LinkGeneric 01/2022 - 05/2017
2	Apolipoproteins D (Apo D)IBA 10/2019 - 06/2009
2	17-alpha-Hydroxyprogesterone (17 Hydroxyprogesterone)IBA 01/2018 - 06/2013
2	Growth Hormone (Somatotropin)IBA 01/2018 - 01/2018
2	CorticosteroneIBA 05/2017 - 06/2013
2	Dehydroepiandrosterone (DHEA)IBA 05/2017 - 01/2012
2	DNA (Deoxyribonucleic Acid)IBA 01/2017 - 01/2013
2	Dehydroepiandrosterone SulfateIBA 01/2017 - 06/2013
2	Glucose (Dextrose)FDA LinkGeneric 07/2014 - 01/2012
2	Dihydrotestosterone (Androstanolone)IBA 06/2013 - 02/2002
2	Insulin (Novolin)FDA Link 06/2013 - 03/2007
2	Mineralocorticoid Receptors (Mineralocorticoid Receptor)IBA 05/2013 - 01/2007
2	Proteins (Proteins, Gene)FDA Link 02/2012 - 04/2008
2	EnzymesIBA 07/2008 - 02/2002
1	ElementsIBA 10/2023
1	ForminsIBA 05/2023
1	Prostate-Specific Antigen (Semenogelase)IBA 05/2023
1	HMGB1 Protein (HMG1)IBA 01/2023
1	Metyrapone FDA Link 01/2023
1	SDMIBA 12/2022
1	Membrane Proteins (Integral Membrane Proteins)IBA 01/2022
1	GonadotropinsIBA 01/2021
1	ProlactinIBA 01/2020
1	Gonadal Steroid Hormones (Sex Hormones)IBA 01/2020
1	Insulin-Like PeptidesIBA 01/2020
1	Insulin-Like Growth Factor Binding Protein 3IBA 01/2020
1	Adrenocorticotropic Hormone (ACTH)FDA Link 10/2019
1	Messenger RNA (mRNA)IBA 10/2019
1	Prednisolone (Predate)FDA LinkGeneric 01/2018
1	AntralIBA 08/2017
1	Anti-Mullerian HormoneIBA 08/2017
1	17-alpha-Hydroxypregnenolone (17 Hydroxypregnenolone)IBA 01/2017
1	AcidsIBA 12/2016
1	LipidsIBA 12/2016
1	Triglycerides (Triacylglycerol)IBA 05/2016
1	Retinaldehyde (Retinal)IBA 05/2016
1	Blood Glucose (Blood Sugar)IBA 05/2016
1	5' Untranslated Regions (5' UTR)IBA 01/2016
1	Bicarbonates (Hydrogen Carbonate)IBA 09/2015
1	ReninIBA 01/2015

Therapy/Procedure

7	Therapeutics 04/2024 - 03/2007
2	Castration 10/2018 - 01/2018
1	Hormone Replacement Therapy (Therapy, Hormone Replacement) 10/2018